POCD 发病机制的研究进展

术后认知功能障碍(Postoperative Cognitive Dysfunction,POCD)的特征性表现是麻醉和手术后认知功能的持续性下降。这种多认知领域的功能需要感觉和广泛的神经学检测来评估,由于不同的检测仪器、不同的时间点和应用不同的统计学方法,因而对POCD一直没有统一的定义,各POCD间的研究也缺乏比较性。因此,进一步阐述POCD的影响因素及发病机制,有利于对POCD的研究建立标准的检测、诊断和防治方法。

Research Advance in the Pathogenesis Studyof Postoperative Cognitive Dysfunction

POCD is characterized by a persistent decline in cognitive function following anesthesia and surgery,identified by preoperative and postoperative cognitive testing.This testing requires a sensitive and comprehensive neuropsy-chological test battery assessing a variety of cognitive domains.However,the investigation and diagnosis of POCD is hampered by the absence of a consensus regarding the tests to be used as well as the operational definition of POCD.Consequently,the comparison between studies investi-gating POCD is difficult.Therefore,further elaboration of POCD factors and pathogenesis,will help establish standards for POCD detection,diagnosis and control methods.