阿托伐他汀治疗慢性阻塞性肺疾病改善肺功能的临床效果分析

目的:探讨阿托伐他汀对改善慢性阻塞性肺疾病肺功能的临床效果。方法:60例C0PD患者随机分为对照组组和治疗组各30例,对照组给予常规治疗,治疗组在对照组的基础上口服阿托伐他汀(20mg/d)。两组患者随访12周,比较分析两组患者肺功能改善情况及生活质量的变化情况。结果:两组治疗前肺功能无明显差异,治疗后两组肺功能较治疗前均有显著改善。治疗组较对照组第1秒用力呼气容积(FEVl)、用力肺活量(Fvc)、FEVl/FVC和FEVI占预计值百分比(FEVl%Pred)等明显改善,差异有显著的统计学意义(P<0.01);并且生活质量评分治疗组明显高于对照组,差异有显著的统计学意义(P<0.01)。结论:阿托伐他汀能明显提高慢性阻塞性肺疾病的肺功能,提高患者的生活质量。

The Clinical Effects of Improving Lung Function for Atorvastatin Treatment of Chronic Obstructive Pulmonary Disease

Objective:To investigate The clinical effects of improving lung function for Atorvastatin treatment of chronic obstructive pulmonary disease.Methods: Sixty C0PD patients were randomly divided into control group and treatment group,30 patients in each group.Control group received conventional therapy,the treatment group were given the oral administration of atorvastatin(20mg / d) based on conventional therapy,Patients were followed up for 12 weeks,And improvement in lung function and quality of life changes in tow groups were compared.Results: There were no significant differences in lung function before treatment in tow groups.Lung function after treatment in two groups were significantly improved.The forced expiratory volume in one second(FEVl),forced vital capacity(Fvc),FEVl / FVC and FEVI% predicted(FEVl% Pred) in treatment group were significantly improved than in the control group,the difference was statistically significant(P<0.01).And quality of life score was significantly higher than the control group,the dif-ference was statistically significant(P<0.01).Conclusions: Atorvastatin can significantly improve lung function and life quality of patients with chronic obstructive pulmonary disease.