| Hsp70 对低氧大鼠海马DG 区神经细胞p53、p-p38 表达的研究 |
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| 引用本文： | 徐强,董大海,高丽莉,徐文,高琨,罗芳,侯顺利,左晶,刘红,闫文,杨银书,卢娟.Hsp70 对低氧大鼠海马DG 区神经细胞p53、p-p38 表达的研究[J].现代生物医学进展,2012,12(3):419-421. |
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| 作者姓名： | 徐强 董大海 高丽莉 徐文 高琨 罗芳 侯顺利 左晶 刘红 闫文 杨银书 卢娟 |
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| 作者单位： | 1. 兰州市中医医院 甘肃兰州730000
2. 兰州军区疾病预防控制中心 甘肃兰州730020 |
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| 基金项目： | 全军重点基金课题(G-867) |
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| 摘 要： | 目的:探讨热休克蛋白70(HSP70)高表达对低氧大鼠海马DG区神经细胞p53、p-p38表达的影响。方法:将大鼠海马DG区神经细胞在41℃温浴1h诱导HSP70高表达,然后低氧培养,Western-blot检测细胞HSP70、p53、p-p38的表达。结果:温浴可以诱导HSP70高表达;HSP70高表达可抑制p53和p-p38表达。结论:HSP70保护低氧诱导的细胞凋亡可能与抑制p53和p-p38表达有关。
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| 关 键 词： | 热休克蛋白70 细胞凋亡 p53 p-p38 |
The Overexpression of HSP70 of the Neurocyte in the Area of Dentate Gyrus(DG)on the p53and p-p38 of Rat’s Hippocampus Under Hypoxia |
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| XU Qiang,DONG Da-Hai,GAO Li-li,XU Wen,GAO Kun,LUO Fang,HOU Shun-li,ZUO Jing
LIU Hong,YAN Wen,YANG Yin-shu,LU Juan.The Overexpression of HSP70 of the Neurocyte in the Area of Dentate Gyrus(DG)on the p53and p-p38 of Rat’s Hippocampus Under Hypoxia[J].Progress in Modern Biomedicine,2012,12(3):419-421. |
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| Authors: | XU Qiang DONG Da-Hai GAO Li-li XU Wen GAO Kun LUO Fang HOU Shun-li ZUO Jing
LIU Hong YAN Wen YANG Yin-shu LU Juan |
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| Institution: | 1 Chinese Medicine Hospital of lanzhou,Lanzhou 730020,China; 2 The Centre of Disease Prevention and Control of Lanzhou Military Command of Chinese PLA.Lanzhou 730020,China) |
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| Abstract: | Objective: To investigate the effect of the HSP70 over-expression on the p53and p-p38 of the neurocyte in the area of dentate gyrus(DG)of rat’s hippocampus under hypoxia.Methods: Neurocyte in the area of dentate gyrus(DG)of rat’s hippocampus was treated in 41℃ for 1h to induced the over-expression of HSP70.Culturing in hypoxiathe.The level of p53 and p-p38 was detected by Western-blot.Results: Warm bath could induced the over-expression of HSP70;The overexpression of HSP70 down-regulated p53 and p-p38.Conclusions: The over-expression of HSP70 inhibited cell apoptosis from hypoxia maybe related to the downregulating of p53 and of p-p38. |
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| Keywords: | Heat shock protein 70 Apoptosis p53 p-p38 |
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