荧光原位杂交技术及其在医学诊断上的应用

荧光原位杂交技术是近年来生物学领域发展起来的将经典的细胞遗传学与分子遗传学结合起来一项新技术。该技术具有广泛的应用潜力,在细胞生物学、分子生物学、医学等众多领域快速发展。本文介绍了荧光原位杂交技术的基本原理和操作方法,并对该技术目前的发展状况以其在医学诊断上的应用进行了阐述。

Fluorescence in Situ Hybridization and it's Medical Application

Fluorescence in situ hybridization(FISH) is a new technique developed in the field of biology in recent years.FISH is a powerful technique that covers a gap between classical cytogenetic and molecular-genetic techniques.By the broad spectrum of application possibilities it leads to important new developments in cytogenetics,medical diagnostics,molecular biology and so on.This review give a brief overview of the principle,operational approach,developments of FISH and it’s medical applications.