代谢综合症患者血清IL-18 水平变化及临床意义

目的:研究血清IL-18与亚代谢综合症(亚MS)、代谢综合症(MS)的关系,探讨生活方式改变(TLC)后IL-18及相关标记物的变化及其临床意义。方法:16例对照组,14例亚MS组,34例MS组;采用自动生化仪测定空腹血脂水平;采用乳胶增强免疫比浊法检测hs-CRP水平;采用ELISA法检测受试者血清IL-18、IL-6和脂联素水平。结果:MS患者血清IL-18水平与腰围有明显相关性(rs=0.45,P<0.01);与亚MS组比较,MS组IL-18水平显著升高(P<0.01);与正常组比较,MS组患者的腰围、体重指数、hs-CRP、IL-6及IL-18显著升高(P<0.05)。TLC后体重减轻5%,MS患者IL-18、IL-6、hs-CRP水平显著降低(P<0.01),脂联素水平显著升高(P<0.01)。结论:IL-18可作为亚MS和MS预测指标,鉴别亚MS与MS,其含量的变化对病情进展的程度及疗效的判定有重要意义。

Changes of Serum IL-18 Levels in Metabolic Syndrome Patients and its Significance

Objective: To study the relationship of serum IL-18 levels with metabolic syndrome(MS) and pre-MS,to investigate after lifestyle modification the changes of serum IL-18 levels and related biomarkers,as well as their clinic significance.Methods: Sub-jects were divided into control group(n=16),pre-MS group(n=14) and MS group(n=34).The automatic biochemistry analyzer was em-ployed to measure the fasting lipid levels.The level of serum high-sensitivity C-reactive protein was detected by immune turbidimetry.The levels of interleukin-18,IL-6 and adiponectin were detected by ELISA.Results: Levels of IL-18 were highly correlated with waist circumference(rs=0.45,P<0.01).Compared with pre-MS group,the level of IL-18 was significantly increased in MS group(P<0.01).When compared with control group,the levels of waist circumference,BMI,hs-CRP,IL-6 and IL-18 showed a significant increase in MS group.Weight loss of at least 5% caused by lifestyle modification significantly decreased the serum IL-18 concentration and levels of IL-6 and hs-CRP(P<0.01),but increased the adiponectin levels.Conclusion: IL-18 may be a useful biomarker for distinguishing MS from pre-MS subjects.The detection of IL-18 and related biomarkers could bring more instructive information in disease severity assessment and prognosis.