Macromolecular naloxone: a novel long-acting polymer-bound drug. |
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| Authors: | G W Pasternak S C March I Parikh S H Snyder P Cuatrecasas |
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| Affiliation: | 1. Departments of Pharmacology and Experimental Therapeutics The Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA;2. Psychiatry and Behavioral Sciences The Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA |
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| Abstract: | A widely applicable, prolonged-action drug delivery system has been developed using naloxone, a pure narcotic antagonist, as a model. The drug is attached to an inert, water soluble polymer by reversible covalent bonds, whose slow cleavage releases active drug. Naloxone, attached to a hydrazine-substituted polysaccharide by a hydrazone bond, antagonizes morphine analgesia more than 25 times longer than free naloxone. |
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