Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men,but not in women

Background: The leptin:adiponectin ratio (L:A ratio) is an independent predictor of carotid intima-media thickness (CIMT).

Objective: To evaluate whether the leptin:high-molecular-weight adiponectin ratio (L:HA ratio) is associated with CIMT in the general population.

Methods: We investigated the relationship between the L:HA ratio and CIMT in 233 Japanese study participants (106 men and 127 women).

Results: After adjustment for confounding factors, CIMT was significantly correlated with the log L:HA ratio (β?=?0.11, p?=?0.014) in men, whereas no correlation was observed in women (β?=?0.01, p?=?0.50).

Conclusion: The L:HA ratio is closely correlated with CIMT in men, but not in women.