Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design |
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Authors: | Vishnu M Patel Bhupendra G Prajapati Madhabhai M Patel |
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Institution: | (1) A.P.M.C. College of Pharmaceutical Education and Research, 383001 Himatnagar, Gujarat State, India;(2) Pharmaceutics Department, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar, 382711 Kherva Mehsana, Gujarat, India |
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Abstract: | The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches
of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol
934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into the Eudragit patches, to provide the patches with bioadhesive
properties and to modify the rate of drug release. The patches, which were prepared by the solvent casting method, were smooth
and elegant in appearance; were uniform in thickness, weight, and drug content; showed no visible cracks; and showed good
folding endurance. A 32 full factorial design was employed to study the effect of independent variables like hydrophilic polymers Carbopol 934 and
PVP K30, which significantly influenced characteristics like swelling index, ex vivo mucoadhesive strength, in vitro drug
release, and ex vivo residence time. A stability study of optimized Eudragit patches was done in natural human saliva; it
was found that both drug and buccal patches were stable in human saliva. It can be concluded that the present buccal formulation
can be an ideal system to improve the bioavailability of the drug by avoiding hepatic first-pass metabolism.
Published: June 22, 2007 |
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Keywords: | Eudragit buccal patch propranolol hydrochloride bioadhesion factorial design |
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