| Nuclear localization of Sindbis virus nonstructural protein nsP2 |
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| 作者姓名： | WANGXIAOZHONG MINGXIAODING |
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| 作者单位： | DepartmentofBiology,BeijingUniversity,BeiJing100871,China |
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| 摘 要： | In early infection, approximately 10% of nonstructural protein nsP2 of Sindbis virus was transported into the nuclei of virus-infected BHK-21 cells. Nuclear asP2 was dominantly associated with nuclear matrix. During the course of infection, increasing amounts of nsP2 accumulated in the nuclear fraction. A prominent accumulation of nuclear nsP2 occurred early in infection, from 1 h to 3 h postinfection. Meanwhile. a weak NTPase activity was found to be associated with the immunocomplexed nsP2. Nuclear localization of nsP2 and its possible role were diseussed in relation to the inhibition of host macromolecular synthesis.
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| 关 键 词： | nsP2 非结构蛋白 核矩阵 辛德毕斯病毒 核定位 |
Nuclear localization of Sindbis virus nonstructural protein nsP2 |
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| WANGXIAOZHONG MINGXIAODING.Nuclear localization of Sindbis virus nonstructural protein nsP2[J].Cell Research,1993,3(1):27-37. |
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| Authors: | WANG XIAOZHONG MINGXIAO DING |
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| Institution: | WANG XIAOZHONG,MINGXIAO DING
Department of Biology,Bejing University,Beijing 100871,China |
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| Abstract: | In early infection, approximately 10% of nonstruc-tural protein nsP2 of Sindbis virus was transported into the nuclei of virus-infected BHK-21 cells. Nuclear nsP2 was dominantly associated with nuclear matrix. During the course of infection, increasing amounts of nsP2 accumulated in the nuclear fraction. A prominent accumulation of nuclear nsP2 occurred early in infection, from 1 h to 3 h postinfection. Meanwhile, a weak NTPase activity was found to be associated with the immunocomplexed nsP2. Nuclear localization of nsP2 and its possible role were discussed in relation to the inhibition of host macro-molecular synthesis. |
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| Keywords: | Sindbis virus nonstructural protein nsP2 nuclear matrix |
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