Antibacterial effects of some 1-substituted 1,2,4-triazoles |
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| Authors: | S Jantová G Greif R Pavlovičová L' Čipák |
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| Institution: | (1) Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia;(2) Department of Saccharides and Food Preservation, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia |
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| Abstract: | Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significant effect on the bacteriaB. subtilis, S. aureus, E. coli andP. aeruginosa. The least sensitive to the effects of the triazoles wasS. aureus. With all triazole derivatives and their combinations,B. subtilis andP. aeruginosa exhibited IC50 and MIC values several times higher than with ampicillin. The most effective triazoles have a N-phenyl ring or benzimidinoyl
ring substituted with one or several chlorine atoms. The highest tested concentration of the three most effective triazoles
influenced the specific growth rate. |
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