Microtubules regulate disassembly of epithelial apical junctions |
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| Authors: | Andrei I Ivanov Ingrid C McCall Brian Babbin Stanislav N Samarin Asma Nusrat Charles A Parkos |
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| Institution: | (1) Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA |
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| Abstract: | Background Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional complex (AJC) which regulates cell-cell
adhesion, paracellular permeability and cell polarity. The AJC is anchored on cytoskeletal structures including actin microfilaments
and microtubules. Such cytoskeletal interactions are thought to be important for the assembly and remodeling of apical junctions.
In the present study, we investigated the role of microtubules in disassembly of the AJC in intestinal epithelial cells using
a model of extracellular calcium depletion. |
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