血管内皮生长因子在乳腺浸润性导管癌组织中的表达及其临床意义

目的:探讨血管内皮生长因子(VEGF)在乳腺浸润性导管癌(IDC))组织中的表达及其与临床病理特征的关系。方法:采用SP免疫组化法检测72例IDC患者(IDC组)和30例乳腺纤维腺瘤(对照组)组织中VEGF的表达。结果:IDC组VEGF阳性表达率为68.1%,显著高于对照组(23.3%),两组相比较有显著性差异(P<0.05);VEGF阳性表达与IDC患者年龄和肿瘤直径大小无相关性,其阳性表达率差异无统计学意义(P>0.05);而VEGF水平与临床分期和病理组织学分级、以及肿瘤远处转移之间存在相关性,其阳性表达率有显著性差异(P<0.05)。结论:VEGF在IDC组织中呈高表达,VEGF参与了IDC发生发展和浸润转移,VEGF可以作为评价IDC恶性程度和淋巴结转移的一个新型指标。

Expression and Clinical Significance of VEGF in Tissues of Patients with Invasive Ductal Carcinoma of Breast

Objective: To study the expression and clinical significance of vascular endothelial growth factor(VEGF) in tissues of patients with invasive ductal carcinoma of breast(IDC).Methods: The VEGF expression from 72 cases of patients with IDC(IDC group) and 30 cases of patients with breast fibroadenoma(control group) tissues were detected by SP immunohistochemical method.Results: The positive rate of VEGF expression of the IDC group was 68.1%,the control group was 23.35%;there was significant difference between the two groups(P <0.05);The positive expression of VEGF was no significant correlation among the different age and tumor diameter,the positive rate of VEGF expression had no significant difference(P>0.05);The positive expression of VEGF was significantly correlated with clinical stage,histological grade and distant metastasis of tumor,the positive rate of VEGF expression had significant difference(P<0.05).Conclusion: The VEGF has high expression in tissues of patients with IDC,the VEGF involves in the 0ccurrence,development,invasion and metastasis of IDC.The VEGF is a new indicator for evaluating the malignant degree and lymph node metastasis of IDC.