心肌造影负荷超声心动图评价存活心肌的临床研究

目的:研究心肌造影负荷超声心动图(MCSE)定量心肌血流判断存活心肌的可行性与可靠性。方法:对20例冠心病患者行持续静脉滴注法MCSE,按1:4的比例于收缩末期触发的方式提取图像,采集图像后脱机分析及彩色编码。计算灌注正常区域和灌注缺损区域的A.β值,根据A.β值确定心肌存活与否,将判定结果正电子断层显像(PET)进行对照。结果:17例病人(85%)获得满意图像,灌注正常区和灌注缺损区的A.β值分别为59.32±11.54和5.69±1.78;灌注正常区在Dob 5μg、10μg时的A.β均值分别为69.57±8.13和76.65±13.61,且均高于静息时A.β值,与PET判定坏死的心肌节段一致。结论:MCSE能从血流定量水平判断存活心肌。

Assessment of Myocardial Viability in Patients with Coronary Heart DiseasebyMyocardial Contrast Stress Echocardiography

Objective: To study the myocardial contrast stress echocardiography(MCSE) for assessment of viable myocardium in patient s with Coronary heart disease(CHD).Methods: Twenty patients with CHD(mean age 55.1 ±12.8years) were studied by MCSE according to the ratio of 1:4 in the way of end-systolic triggering time.Calculation the A·β value of the perfusion of normal region and the perfusion defect area,according to A·βvalue determination of myocardial viability or not,the result of determination of PET control.Results: In 17 patients(85%) obtained a satisfactory image,perfusion of normal and perfusion defect area A·βvalues were 59.32 + 11.54 and 5.69 + 1.78;Perfusion of normal area in Dob 5g,10g,A·βvalue mean were 69.57 + 8.13 and 76.65 + 13.61,are higher than the rest-ing A·βvalue,and PET to determine myocardial necrosis segment alignment.Conclusions: MCSE can evaluate myocardial via-bility from blood flow quantitative level.