个体化美罗培南治疗铜绿假单胞菌感染老年患者的临床经验

目的:探讨个体化美罗培南对感染铜绿假单胞菌老年患者的有效性及安全性。方法:110例经细菌培养已证实铜绿假单胞菌感染的老年肺部感染患者,随机分成两组,美罗培南常规剂量组和公式定量法剂量组(个体化组),分析两组美罗培南的疗效及安全性。结果:个体化剂量组的美罗培南平均用药0.8 g/12 h较常规剂量组的1.0 g/12 h低。个体化剂量组的有效率为78.2%高于常规剂量组的63.6%,但两组差异无显著性(P>0.05)。轻度不良反应的发生率个体化剂量组高(P<0.05),两组未发生肝功能异常病例,常规剂量美罗培南对肾功能有一定影响,而个体化用药能减轻美罗培南对肾功能的影响。结论:美罗培南个体化给药治疗铜绿假单胞菌感染的老年肺部感染患者可以在保证疗效的前提下提高安全性,减少对肾功能的影响。

Clinical Experience of Individualized Dosing of Meropenem for Pseudomonas Aeruginosa Infection in Elderly Patients

Objective: To compare an individualized dosing regimen for Meropenem to conventional dosing for pseudomonas aeruginosa infection in elderly patients,assess the efficacy of two methods,and safety.Methods: 110 Bacterial culture confirmed Pseu-domonas aeruginosa infection in hospitalized patients,were randomly divided into two groups by the usual dose and formula,evaluation of two methods of Meropenem efficacy and safety.Results: Individual dosing of meropenem with the average drug 0.8 g/12 h compared to the conventional low-dose group with 1.0 g/12 h.The effective individual dose group was 78.2 %,63.6 % of conventional dose group,the difference was no significant(P>0.05).Mild adverse reactions were higher in the individualized dosing group than the conventional dosing group(P<0.05),liver dysfunction did not occur in both groups,conventional dose of meropenem had a certain influence on renal function,individual dosing of meropenem could reduce Conclusios: Meropenem individual administration can be effective in ensuring control of Pseudomonas aeruginosa infection,and reduce the the influence on renal function.