|
|||||
|
|
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties |
|
| Authors: | Regan Colin F Guo Zhiqiang Chen Yongsheng Huang Charles Q Chen Mi Jiang Wanlong Rueter Jaimie K Coon Timothy Chen Chen Saunders John Brown Michael S Betz Steve F Struthers R Scott Yang Chun Wen Jenny Madan Ajay Zhu Yun-Fei |
| Institution: | Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12780 El Camino Real, San Diego, CA 92130, USA. |
| Abstract: | A novel series of potent zwitterionic uracil GnRH antagonists were discovered that showed reduced liability for CYP3A4 enzyme inhibition. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |