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Coronavirus infection of polarized epithelial cells |
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| Authors: | John W. A. Rossen Marian C. Horzinek Peter J. M. Rottler |
| Affiliation: | Virology Divn of the Dept of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL, Utrecht, The Netherlands |
| Abstract: | Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins. |
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