Birth and death of gene overlaps in vertebrates |
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| Authors: | Izabela Makałowska Chiao-Feng Lin Krisitina Hernandez |
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| Affiliation: | (1) The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA;(2) Institute of Molecular Evolutionary Genetics and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA;(3) Institute of Bioinformatics, University of Muenster, 48149 Muenster, Germany |
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| Abstract: | Background Between five and fourteen per cent of genes in the vertebrate genomes do overlap sharing some intronic and/or exonic sequence. It was observed that majority of these overlaps are not conserved among vertebrate lineages. Although several mechanisms have been proposed to explain gene overlap origination the evolutionary basis of these phenomenon are still not well understood. Here, we present results of the comparative analysis of several vertebrate genomes. The purpose of this study was to examine overlapping genes in the context of their evolution and mechanisms leading to their origin. |
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