胃癌的肿瘤微环境研究进展

肿瘤微环境是决定肿瘤细胞行为的主要影响因素,有别于正常细胞与其周围组织所形成的微环境,组织缺氧和酸中毒、间质高压形成、大量生长因子和蛋白水解酶的产生及免疫炎性反应等构成了肿瘤组织代谢环境的生物学特征,这种特性在肿瘤的发生、进展、转移中扮演重要的角色。胃癌早期症状不典型、转移迅速、死亡率高,是消化系统最常见的恶性肿瘤,目前,关于肿瘤微环境的研究尚处于起步阶段,对胃癌肿瘤微环境的研究有助于我们进一步认识胃癌发生发展的机制,并为临床诊断、治疗胃癌提供依据。因此,本文就近年来在胃癌肿瘤微环境方面的研究进展作一综述。

Research Progress of Gastric Tumor Microenvironment

The tumor microenvironment is one of the main factors to determine the behavior of tumor cells which is different fromnormal cells and their surrounding tissue microenvironment, tissue hypoxia and acidosis, interstitial hypertension, a large number of growth factors and generation of proteolytic enzymes and immune inflammatory reactions constitute the biological characteristics of the tumor tissue metabolic environment. This feature plays an important role in tumorigenesis, progression, and metastasis. Gastric cancer early symptoms are not typical, rapid transfer of high mortality, is the most common malignant tumors of the digestive system, the research is still in its infancy on the tumor microenvironment, the gastric tumor microenvironment helps to further our knowledge of gastric cancer the development of mechanisms for clinical diagnosis, and to provide basis for the treatment of gastric cancer. Therefore, this paper reviewed the recent research progress in gastric tumor microenvironment.