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Anticipatory evolution and DNA shuffling |
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| Authors: | Bacher Jamie M Reiss Brian D Ellington Andrew D |
| Affiliation: | (1) Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712 Austin, TX, USA;(2) Center for Nano- and Molecular Science and Technology, University of Texas at Austin, 78712 Austin, TX, USA;(3) Department of Chemistry and Biochemistry, University of Texas at Austin, 78712 Austin, TX, USA; |
| Abstract: | DNA shuffling has proven to be a powerful technique for the directed evolution of proteins. A mix of theoretical and applied research has now provided insights into how recombination can be guided to more efficiently generate proteins and even organisms with altered functions. |
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