Modulation of redox homeostasis under suboptimal conditions by Arabidopsis nudix hydrolase 7 |
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| Authors: | Niranjani Jambunathan Anuradha Penaganti Yuhong Tang Ramamurthy Mahalingam |
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| Institution: | (1) 246 Noble Research Center, Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, USA;(2) The Samuel Roberts Noble Foundation Inc., Plant Biology Division, Ardmore, Oklahoma, USA |
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| Abstract: | Background Nudix hydrolases play a key role in maintaining cellular homeostasis by hydrolyzing various nuceloside diphosphate derivatives
and capped mRNAs. Several independent studies have demonstrated that Arabidopsis nudix hydrolase 7 (AtNUDT7) hydrolyzes NADH and ADP-ribose. Loss of function Atnudt7-1 mutant plants (SALK_046441) exhibit stunted growth, higher levels of reactive oxygen species, enhanced resistance to pathogens.
However, using the same T-DNA line, two other groups reported that mutant plants do not exhibit any visible phenotypes. In
this study we analyze plausible factors that account for differences in the observed phenotypes in Atnudt7. Secondly, we evaluate the biochemical and molecular consequences of increased NADH levels due to loss of function of AtNUDT7
in Arabidopsis. |
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