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Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology |
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| Authors: | Lee Ji-Soo Chung Donghwa Lee Hyeon Gyu |
| Affiliation: | aDepartment of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea bFaculty of Marine Bioscience and Technology, Kangnung National University, Gangneung, Gangwon 210-702, Republic of Korea |
| Abstract: | Response surface methodology was used to optimize bead preparation conditions, including CaCl2 concentration (X1), hydroxypropylmethylcellulose concentration (X2), and bead-hardening time (X3), for the sustained-release of catechin from the calcium pectinate gel beads reinforced with liposomes and hydroxypropylmethylcellulose into simulated gastric fluid (SGF) and intestinal fluid (SIF). The optimized values of X1, X2, and X3 were found to be 5.82%, 0.08%, and 10.29 min, respectively. The beads prepared according to the optimized conditions released only about half of the entrapped catechin into SGF while most of the entrapped catechin was released into SIF after 24 h incubation. |
| Keywords: | Catechin Calcium pectinate gel beads Response surface methodology |
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