|
|||||
|
|
Effect of taurine on ATP-dependent calcium transport in guinea-pig cardiac muscle |
|
| Authors: | Mohamed A. Remtulla Sidney Katz Derek A. Applegarth |
| Affiliation: | Division of Pharmacology, Faculty of Pharmaceutical Sciences and Departments of Pediatrics & Pathology, Faculty of Medicine, University of British Columbia, and Biochemical Diseases Laboratory, Children''s Hospital, Vancouver, B.C., Canada |
| Abstract: | The effect of taurine on ATP-dependent calcium transport was examined in guinea-pig cardiac ventricle homogenates and in microsomal preparations enriched in sarcoplasmic reticulum. Taurine (5?50 mM) did not affect ATP-dependent calcium binding or uptake in either of these preparations or alter the rate of decay of calcium uptake activity. Taurine (20 mM) also did not affect the oxalate-dependent calcium uptake stimulation noted in the presence of cyclic AMP-dependent protein kinase and cyclic AMP. The mechanism by which taurine alters cardiac function remains to be elucidated. |
| Keywords: | Correspondence to: Dr. Sidney Katz Division of Pharmacology Faculty of Pharmaceutical Sciences University of British Columbia Vancouver B.C. Canada V6T 1W5. |
| 本文献已被 ScienceDirect 等数据库收录！ | |