Understanding topoisomerase I and II in terms of QSAR |
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Authors: | Verma Rajeshwar P |
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Institution: | Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu |
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Abstract: | A variety of antitumor agents currently used in chemotherapy or evaluated in clinical trials are known to inhibit DNA topoisomerase I or II. We have developed sixteen quantitative structure-activity relationships (QSAR) for different sets of compounds that are camptothecin analogs, 1,4-naphthoquinones, unsaturated acids, benzimidazoles, quinolones, and miscellaneous fused heterocycles to understand chemical-biological interactions governing their inhibitory activities toward topoisomerase I and II. |
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