The effects of prostaglandins PGE1, PGE2, PGF1a, and PGF2a on canine synovial perfusion |
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| Authors: | D M Grennan I J Zeitlin W S Mitchell W W Buchanan W C Dick |
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| Institution: | The Centre for Rheumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow, Department of Physiology and Pharmacology, University of Strathclyde, Glasgow and the Wellcome Surgical Research Institute, Glasgow, USA |
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| Abstract: | In these experiments we have examined the effects of PGE1, PGE2, PGF1α and PGF2α on synovial perfusion in the normal canine synovial microcirculation. The effects of the drugs on synovial perfusion were determined indirectly from the changes produced in the rate of clearance of 133Xenon from the joint by their intra-articular injection. Prostaglandins PGE1 and PGE2 were found to be strongly vasodilator with PGE1 being the more active. PGF1α appeared to have little or no vasoactive properties in doses up to 1 ugm. (2.8 × 10−5M) in our I preparation while PGF2α was vasodilator at this high dosage only. Neither SC19920 nor diphloretin phosphate antagonised the effects of PGE1 in these experiments. |
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