Calcineurin—immunosuppressor complexes |
| |
Authors: | Barry L Stoddard Karen E Flick |
| |
Institution: | Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104-2092, USA |
| |
Abstract: | Crystal structures of the Ser/Thr phosphatase calcineurin (protein phosphatase 2B) have recently been solved by X-ray crystallography, both in the free-protein state, and complexed with the immunophilin/immunosuppressant FKBP12/FK506. Core elements of the calcineurin phosphatase have been found to be similar to the corresponding elements of Ser/Thr phosphatase 1 and purple acid phosphatase. The structures provide a basis for understanding calcineurin inhibition by a ternary complex of immunophilin and immunosuppressant proteins. |
| |
Keywords: | Abbreviations: CaN calcineurin CsA cyclosporin A IL interleukin KBPAP kidney bean PAP PAP purple acid phosphatase PP protein phosphatase |
本文献已被 ScienceDirect 等数据库收录! |