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利用海洋硅藻生产生物活性物质研究进展*
引用本文:张虎,刘镇洲,陈家敏,高保燕,张成武.利用海洋硅藻生产生物活性物质研究进展*[J].中国生物工程杂志,2021,41(4):81-90.
作者姓名:张虎  刘镇洲  陈家敏  高保燕  张成武
作者单位:暨南大学水生生物研究中心 广州 510632
基金项目:*国家自然科学基金(32002412);中央高校基本科研业务费专项资金资助项目(21619305)
摘    要:生物活性物质在食品、饵料、化妆品、保健品和医药等行业具有广阔的应用前景,其研究早已受到广泛关注。鉴于海洋硅藻具有生长速度快、生物活性物质含量高、易于规模培养、便于提取等诸多优势,为理想的生物活性物质生产者。尽管国内外已进行了大量利用海洋硅藻生产生物活性物质的研究,但是受限于培养工艺老旧、生产成本过高等缺陷,商业化利用海洋硅藻开发生物活性物质依然停滞不前。阐述海洋硅藻五种常见生物活性物质的应用价值,进一步探讨海洋硅藻高产生物活性物质的策略,就如何低成本、高效开发利用硅藻源生物活性物质提出建议,为海洋硅藻商业化开发利用提供参考。

关 键 词:海洋硅藻  生物活性物质  筛选  环境因子  培养模式  
收稿时间:2020-12-28

Research Progress on the Production of Bioactive Compounds from Marine Diatoms
ZHANG Hu,LIU Zhen-zhou,CHEN Jia-min,GAO Bao-yan,ZHANG Cheng-wu.Research Progress on the Production of Bioactive Compounds from Marine Diatoms[J].China Biotechnology,2021,41(4):81-90.
Authors:ZHANG Hu  LIU Zhen-zhou  CHEN Jia-min  GAO Bao-yan  ZHANG Cheng-wu
Abstract:Bioactive compounds have a broad range of applications in food, feed, cosmetic, nutraceutical, and pharmaceutical industries. Thus, the studies of bioactive compounds have been gaining great attention from science and the public in recent decades. Given the advantages of fast growth, high content of bioactive compounds, easy to be cultured and scaled up, and effective biorefinery, marine diatoms were considered to be the most promising producers of natural bioactive compounds. Although a large number of studies have been carried out to enhance the production of bioactive compounds from marine diatoms, a commercial production scale has seldom been realized due to several intrinsic shortcomings such as old culture technology and high production cost. This review aims to provide an overview of bioactive compounds from marine diatoms and their high production strategies. The path forward for further commercial production of the bioactive compounds from marine diatoms with respect to 3 different opportunities is also discussed, which will in turn accelerate the development of microalgae industry and provide support for human health and high-quality life.
Keywords:Marine diatoms  Bioactive compounds  Screening  Environmental factors  Culture mode  
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