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Exploring phenotype space through neutral evolution |
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| Authors: | Martijn A Huynen |
| Institution: | (1) Theoretical Biology and Biophysics, Los Alamos National Laboratory, MS-K710, Los Alamos, NM 87545, USA, US;(2) Center for Nonlinear Studies, Los Alamos National Laboratory, MS-B258, Los Alamos, NM 87545, USA, US;(3) Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA, US |
| Abstract: | RNA secondary-structure folding algorithms predict the existence of connected networks of RNA sequences with identical secondary structures. Fitness landscapes that are based on the mapping between RNA sequence and RNA secondary structure hence have many neutral paths. A neutral walk on these fitness landscapes gives access to a virtually unlimited number of secondary structures that are a single point mutation from the neutral path. This shows that neutral evolution explores phenotype space and can play a role in adaptation. Received: 23 December 1995 / Accepted: 17 March 1996 |
| Keywords: | : RNA secondary structure — Neutral Evolution — Adaptive evolution — Genotype-phenotype relation — Sequence space — Fitness landscape |
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