| 流感病毒的分子生物学研究进展 |
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| 引用本文： | 张伟,王承宇,杨松涛,高玉伟,夏咸柱. 流感病毒的分子生物学研究进展[J]. 中国实验动物学杂志, 2010, 0(4): 74-79 |
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| 作者姓名： | 张伟 王承宇 杨松涛 高玉伟 夏咸柱 |
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| 作者单位： | [1]中国医学科学院医学实验动物研究所北京协和医学院比较医学中心,北京100021 [2]军事医学科学院军事兽医研究所,长春130062 |
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| 基金项目： | 国家科技支撑计划项目（No.2010BAD04B01） |
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| 摘 要： | 流感病毒是分节段的负链RNA病毒,由RNA依赖的RNA聚合酶起始病毒的复制。流感病毒的特殊基因组结构和病毒蛋白的功能使其极易发生抗原转换和抗原漂移,这使得病毒能够逃避多种宿主的长效中和性免疫反应。本文从病毒结构、基因组及其编码蛋白质、病毒复制过程和病毒的易感宿主等几方面论述了流感病毒的分子生物学研究进展。
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| 关 键 词： | 流感病毒 RNA病毒 抗原转换 抗原漂移 |
Advances in Research on Molecular Biology of Influenza Virus |
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| ZHANG Wei,WANG Cheng-yu,YANG Song-tao,GAO Yu-wei,XIA Xian-zhu. Advances in Research on Molecular Biology of Influenza Virus[J]. Chinese Journal of Laboratory Animal Science, 2010, 0(4): 74-79 |
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| Authors: | ZHANG Wei WANG Cheng-yu YANG Song-tao GAO Yu-wei XIA Xian-zhu |
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| Affiliation: | 1.Comparative Medicine Centre,Peking Union Medical College(PUMC);Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences(CAMS),Beijing 100021,China;2.Veterinary Institute,Academy of Military Medical Sciences,Changchun 130062,China) |
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| Abstract: | Influenza virus,a member of the Orthomyxoviridae family,is an enveloped RNA virus with a genome in the form of eight segments requiring an RNA dependent RNA polymerase of viral origin for replication.Influenza viruses can escape the long-term neutralizing antibody response in many hosts via ever-changing antigenic shift and antigenic drift resulting from the particular structure of the virus genome and function of its viral proteins.In this paper,the structure of virus,the genome and encoding proteins of virus,the replication process and susceptible hosts will be summarized. |
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| Keywords: | Influenza virus RNA virus Antigenic shift Antigenic drift |
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