Cadmium and mercury levels in saudi women and its possible relationship with hypertension |
| |
Authors: | Iman Al-Saleh Neptune Shinwari Abdullah Mashhour Gamal El-Din Mohamed Mohammad Abu Ghosh Zaki Shammasi Abdulazi Al-Nasser |
| |
Institution: | (1) Department of Biological & Medical Research, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia;(2) Department of Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia;(3) Department of Family Medicine & Polyclinics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia |
| |
Abstract: | The association between elevated blood pressure and blood cadmium and mercury levels was examined (2001–2002) in 185 Saudi
women previously selected for a case-control study of lead and hypertension risk. Blood pressure was measured twice according
to the World Health Organization recommendations. Cadmium and mercury were determined with graphite furnace and hydride system-atomic
absorption spectrometry, respectively. Mean blood cadmium concentrations were 0.874±0.995 μg/L in hypertensive and 0.785±0.665
μg/L in controls. While blood mercury concentrations for hypertensives and controls were 3.506±3.617 μg/L and 3.687±3.186
μg/L, respectively. Participants were classified according to the median of blood cadmium and mercury levels. After adjustment
for potentially confounding variables, the final logistic regression analyses revealed that women with blood cadmium ≥0.627
μg/L were 3.934 times were more likely to be hypertensive than those with blood cadmium levels <0.627 μg/L, although this
was marginally significant (p=0.098). This was likely the result of the small number of subjects, resulting in the weak power to detect a strong significant
difference between hypertensives and control cases. On the other hand, the final regression model showed no association between
hypertension and mercury. However, this finding should not be conclusive because of the inappropriate choice of the biomarker
indicator. Nevertheless, our study supports the hypothesis that exposure to cadmium might increase the risk of hypertension. |
| |
Keywords: | Cadmium mercury lead hypertension systolic blood pressure diastolic blood pressure women Saudi Arabia |
本文献已被 PubMed SpringerLink 等数据库收录! |
|