| A Cytotoxic Neolignan from Schisandra propinqua （Wall.） Baill. |
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| 引用本文： | Li-Jia Xu Feng Huang Si-Bao Chen Lian-Niang Li Shi-Lin Chen Pei-Gen Xiao. A Cytotoxic Neolignan from Schisandra propinqua （Wall.） Baill.[J]. 植物学报(英文版), 2006, 48(12): 1493-1497. DOI: 10.1111/j.1744-7909.2006.00323.x |
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| 作者姓名： | Li-Jia Xu Feng Huang Si-Bao Chen Lian-Niang Li Shi-Lin Chen Pei-Gen Xiao |
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| 作者单位： | [1]Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, China [2]State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen 518057, China [3]Department of Appfied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong SAR, China [4]Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China |
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| 基金项目： | The authors are grateful to Prof. Ce-Ming Tan, Institute of Forest Science, Jiujiang, Jiangxi Proince, China, for the collection of plant material. They are also indebted to Prof. Guan-Hua Du, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, for assistance with bioactivity testing. |
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| 摘 要： | In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound was determined to be 4, 4-di （4-hydroxy-3-methoxyphenly）-2, 3-dimethylbutanol （compound 1） on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-（4,5-dimethyl-2 thiazoyl）-2,5-diphenyl-2H- tetrazolium bromide （MTT） assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.
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| 关 键 词： | 细胞毒素 五味子 植物 研究 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2005-12-192006-04-08 |
A Cytotoxic Neolignan from Schisandra propinqua (Wall.) Baill. |
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| Li-Jia Xu,Feng Huang,Si-Bao Chen,Lian-Niang Li,Shi-Lin Chen , Pei-Gen Xiao. A Cytotoxic Neolignan from Schisandra propinqua (Wall.) Baill.[J]. Journal of integrative plant biology, 2006, 48(12): 1493-1497. DOI: 10.1111/j.1744-7909.2006.00323.x |
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| Authors: | Li-Jia Xu Feng Huang Si-Bao Chen Lian-Niang Li Shi-Lin Chen Pei-Gen Xiao |
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| Affiliation: | Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100094, China;;State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen 518057, China;;Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong SAR, China;;Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China |
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| Abstract: | In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua (Wall.) Baill. The structure of the new compound was determined to be 4, 4‐di (4‐hydroxy‐3‐methoxyphenly)‐2, 3‐dimethylbutanol (compound 1) on the basis of 1H‐ and 13C‐NMR spectra and 2D NMR methods. Eight known compounds, compounds 2‐9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1‐4 were evaluated for cytotoxicity by an 3‐(4,5‐dimethyl‐2 thiazoyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay. Compound 1 showed significant potential cytotoxic ability in the bioassay. (Managing editor: Wei Wang) |
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| Keywords: | cytotoxicity lignan Schisandra propinqua Schisandraceae |
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