STUDIES ON FORMATION OF γ-GLUTAMYLAMINES IN RAT BRAIN AND THEIR SYNTHETIC AND CATABOLIC ENZYMES |
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| Authors: | M. TSUJI Y. MATSUOKA T. NAKAJIMA |
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| Affiliation: | Department of Neuropharmacology and Neurochemistry (Neurology), The Institute of Higher Nervous Activity, Osaka University Medical School, Fukushima-ku, Osaka, Japan |
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| Abstract: | ![]()
γ-Glutamylation of p-tyramine, noradrenaline, dopamine and serotonin in rat brains was demonstrated by intraventricular injections of the radioactive amines and isolation of the γ-glutamylamines from the acidic extract of the rat brains. Formation of these γ-glutamylamines was proved to be catalysed by γ-glutamyltranspeptidase prepared from both rat kidney and brain. However, these compounds were degraded by γ-glutamylcyclotransferase of rat brain, but not by the emzyme of rat kidney. |
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