An efficient, practical synthesis of 2-methoxyestradiol |
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| Authors: | Minhang Xin |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China |
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| Abstract: | An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17β-estradiol as starting material gave 2-methoxyestradiol with a 61% overall yield. |
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| Keywords: | 2-Methoxyestradiol Copper-mediated methoxylation Ethyl acetate Co-catalyst Synthesis |
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