Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus |
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| Authors: | Emily HM Wong David K Smith Raul Rabadan Malik Peiris Leo LM Poon |
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| Affiliation: | (1) Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong, China;(2) Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China;(3) Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics, Columbia University College of Physicians and Surgeons, New York, USA |
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| Abstract: | Background The influenza A virus is an important infectious cause of morbidity and mortality in humans and was responsible for 3 pandemics in the 20th century. As the replication of the influenza virus is based on its host's machinery, codon usage of its viral genes might be subject to host selection pressures, especially after interspecies transmission. A better understanding of viral evolution and host adaptive responses might help control this disease. |
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