| 长链非编码RNA在脂质代谢中的作用 |
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| 引用本文： | 张杨恺,胡密,林惠玲,唐宛莹,欧阳雨欣,何平平,欧阳新平.长链非编码RNA在脂质代谢中的作用[J].生物化学与生物物理进展,2023,50(12):2913-2924. |
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| 作者姓名： | 张杨恺 胡密 林惠玲 唐宛莹 欧阳雨欣 何平平 欧阳新平 |
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| 作者单位： | 1)南华大学附属长沙中心医院,长沙 410004;3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013,3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013,3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013,3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013,3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013,2)湖南师范大学医学院生理学教研室,长沙 410000,2)湖南师范大学医学院生理学教研室,长沙 410000;3)南华大学衡阳医学院基础医学院生理学教研室,神经科学研究所,神经变性与认知障碍衡阳市重点实验室,衡阳 410013 |
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| 基金项目： | 国家自然科学基金（82170485） 和教育部产学合作协同育人项目 （202002138007） 资助。 |
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| 摘 要： | 脂质代谢是人体三大代谢之一,在激素等信号分子的调控下,脂质代谢处于稳定平衡的状态。当稳态被打破,血液中甘油三酯（triglyceride,TG）、胆固醇等水平发生变化,最终引起动脉粥样硬化（atherosclerosis,AS）、肥胖等脂质代谢疾病。长链非编码RNA（long noncoding RNA,lncRNA）是一组不具备蛋白质编码能力,长度大于200个核苷酸的RNA,近来研究发现,lncRNA与机体代谢、炎症和免疫系统以及血管功能的调控密切相关。大量文献表明,lncRNA参与脂质代谢调控,因而有望成为一些脂质代谢疾病的潜在治疗靶点。
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| 关 键 词： | 长链非编码RNA 脂质 脂质代谢 胆固醇 |
| 收稿时间： | 2022/8/5 0:00:00 |
| 修稿时间： | 2023/11/5 0:00:00 |
Role of LncRNAs in Lipid Metabolism |
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| ZHANG Yang-Kai,HU Mi,LIN Hui-Ling,TANG Wan-Ying,OUYANG Yu-Xin,HE Ping-Ping and OUYANG Xin-Ping.Role of LncRNAs in Lipid Metabolism[J].Progress In Biochemistry and Biophysics,2023,50(12):2913-2924. |
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| Authors: | ZHANG Yang-Kai HU Mi LIN Hui-Ling TANG Wan-Ying OUYANG Yu-Xin HE Ping-Ping and OUYANG Xin-Ping |
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| Institution: | 1)The Affiliated Changsha Central Hospital, University of South China, Changsha 410004, China;3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China,3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China,3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China,3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China,3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China,2)Department of Physiology, Medical College of Hunan Normal University, Changsha 410013, China,2)Department of Physiology, Medical College of Hunan Normal University, Changsha 410013, China;3)Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Basic Medical School, Hengyang Medical College, University of South China, Hengyang 410013, China |
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| Abstract: | Lipid metabolism is one of the three major metabolisms in human body. Lipid metabolism is usually in a balanced state under the regulation of hormones and other signaling factors. When the homeostasis is disrupted, the level of triglyceride (TG) and cholesterol in the blood changes, eventually causing atherosclerosis (AS), obesity and other lipid dysfunction diseases. Long non-coding RNA (lncRNA) is a group of RNAs that do not have the ability to code proteins with more than 200 nucleotides in length. Recent studies have found that lncRNAs are closely related to the regulation of metabolism, inflammation, immune system, and vascular function. A large body of research suggests that lncRNAs are involved in the regulation of lipid metabolism and thus are expected to be potential therapeutic targets for some lipid metabolic diseases. |
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| Keywords: | long non-coding RNA lipids lipid metabolism cholesterol |
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