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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Authors:Ling Liu  Xiaoyang Su  William J Quinn  Sheng Hui  Kristin Krukenberg  David W Frederick  Philip Redpath  Le Zhan  Karthikeyani Chellappa  Eileen White  Marie Migaud  Timothy J Mitchison  Joseph A Baur  Joshua D Rabinowitz
Institution:1. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA;2. Department of Chemistry, Princeton University, Princeton, NJ 08540, USA;3. Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08904, USA;5. Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;6. Department of System Biology, Harvard Medical School, Boston, MA 02115, USA;7. Shire, Lexington, MA 02421, USA;8. School of Pharmacy, Queen''s University Belfast, Belfast, Northern Ireland BT9 7BL, UK;9. Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA;10. Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
Abstract:
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  • Keywords:nicotinamide  NAD  NADH  mass spectrometry  isotope tracers  flux quantification  redox cofactor  riboside  mononucleotide  niacin
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