In situ activation of murine macrophages by liposomes containing lymphokines |
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Authors: | William E Fogler Avraham Raz Isaiah J Fidler |
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Institution: | Cancer Metastasis and Treatment Laboratory, NCI Frederick Cancer Research Center, P.O. Box B, Frederick, Maryland 21701 U.S.A. |
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Abstract: | Murine alveolar and peritoneal macrophages harvested after injection of lymphokines encapsulated within multilamellar phospholipid vesicles (liposomes) were tumoricidal in vitro. The state and degree of activation depended on the route of liposome administration. Activation of peritoneal macrophages was achieved by intraperitoneal injection of liposomes and alveolar macrophages were activated by injecting liposomes intravenously but not intraperitoneally. The in vivo rendering of macrophages with tumoricidal properties might be useful toward destruction of tumor cells in vivo. |
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Keywords: | To whom requests for reprints should be sent |
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