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| DNA疫苗安全性的策略探究 | |
| 引用本文： | 程驰,章欢,赵先平,高荣.DNA疫苗安全性的策略探究[J].四川动物,2012,31(2):328-331. |
| 作者姓名： | 程驰 章欢 赵先平 高荣 |
| 作者单位： | 1. 四川理工学院生物工程学院,四川自贡643000;生物资源与生态环境教育部重点实验室,四川大学生命科学学院,成都610064 2. 川北医学院基础医学院生物学教研室,四川南充,637000 3. 四川理工学院生物工程学院,四川自贡,643000 4. 生物资源与生态环境教育部重点实验室,四川大学生命科学学院,成都610064 |
| 摘 要： | DNA疫苗安全性问题主要来自DNA疫苗元件和疫苗工程菌,包括DNA疫苗与宿主基因组整合、接种后诱导宿主产生免疫耐受和自身免疫疾病、抗性基因的转移问题、疫苗中内毒素和抗生素及其他有害物质残留问题、宿主菌体内DNA复制与纯化过程中基因稳定性问题。本文针对这些问题进行策略上的探讨,为进一步开发安全的DNA疫苗提供帮助。 |
| 关 键 词： | DNA疫苗 元件 工程菌 安全性 策略 |
Discussion on Strategies for the Safety of DNA Vaccines |
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| CHENG Chi , ZHANG Huan , ZHAO Xian-ping , GAO Rong.Discussion on Strategies for the Safety of DNA Vaccines[J].Sichuan Journal of Zoology,2012,31(2):328-331. | |
| Authors: | CHENG Chi ZHANG Huan ZHAO Xian-ping GAO Rong |
| Institution: | 3* (1.Department of Biology Engineering,Sichuan University of Science & Engineering,Zigong,Sichuan Province 643000,China;2.Biology Group of North Sichuan Medical College,Nanchong,Sichuan Province 637000,China;3.Key Lab for Biological Resource and Ecological Environment of Education Ministry,College of Life Sciences,Sichuan University,Chengdu 610064,China) |
| Abstract: | The safety issues of DNA vaccines derive mostly from two counterparts,genetic elements and production host bacteria,which include integration of plasmid DNA with host genome,induced immune tolerance and autoimmune diseases by DNA vaccination,side effects of proteins encoded by undesired genes in vaccine,spread or transferability of antibiotic resistance genes,residue of endotoxin and antibiotics in vaccines as well as plasmid genetic instability during duplication and purification.Here,the paper discussed these issues and summarized some valuable strategies for the future development of safe DNA vaccines. |
| Keywords: | DNA vaccine element engineering bacterium safety strategy |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |