Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells |
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| Authors: | Löhr Marianne Kibler Karen V Zachary Ian Jeang Kuan-Teh Selwood David L |
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| Institution: | The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK. |
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| Abstract: | Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity. |
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| Keywords: | Human immunodeficiency virus Tat protein Chemokine receptor Cyclic peptide |
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