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Synthesis and bioactivity studies of 1-adamantanamine derivatives of peptides |
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| Authors: | &#x;tefica Horvat Lidija Varga-Defterdarovi Jaroslav Horvat Rua Juki&#x; Darko Kantoci Nga N Chung Peter W Schiller Lothar Biesert Andreas Pfützner Haryadi Suhartono Helga Rübsamen-Waigmann |
| Institution: | Štefica Horvat,Lidija Varga-Defterdarovič,Jaroslav Horvat,Ruža Jukić,Darko Kantoci,Nga N. Chung,Peter W. Schiller,Lothar Biesert,Andreas Pfützner,Haryadi Suhartono,Helga Rübsamen-Waigmann |
| Abstract: | Small enkephalin-related peptides containing a 1-adamantanamine moiety coupled through an amide linkage at the C-terminus were synthesized. Several of the compounds showed high μ opioid activity and μ receptor selectivity. The new adamantanamine derivatives were also examined for antiviral activity against HIV-1 in a cell culture system. Some of them inhibited syncytia formation even when the antigen assay gave evidence for viral replication. |
| Keywords: | 1-Adamantanamine peptide synthesis opioid compounds antiviral agents HIV-1 |