Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase |
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| Authors: | Lee Jinho Kim Jonghyun Koh Jong Sung Chung Hyun-Ho Kim Kyoung-Hee |
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| Affiliation: | Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Republic of Korea. jinho@kmu.ac.kr |
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| Abstract: | ![]()
1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. |
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