Immunohistochemical distribution of calcitonin gene-related peptide in nerve fibres of the anterior buccal gland of the rat |
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Authors: | J T?rnwall Y T Konttinen and H Uusitalo |
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Institution: | (1) Institute of Biomedicine, Department of Anatomy, University of Helsinki, Siltavuorenpenger 20 A, PO Box 9, FIN-00014 Helsinki, Finland;(2) Department of Clinical Sciences, University of Tampere, PO Box 607, FIN-33521 Tampere, Finland |
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Abstract: | Summary Calcitonin gene-related peptide immunoreactive (CGRP-IR) nerves in rat were studied as to their distribution and origin in
anterior buccal glands, which are unique minor mucous salivary glands in the rat. A moderate number of CGRP-IR nerve fibres
were located, mostly perivascularly and around intralobular ducts, but they were also found around acini. The latter fibres
were mainly of sensory origin, as suggested by their disappearance after denervation of the ophthalmic and maxillary branches
of the trigeminal nerve. On the contrary, CGRP-IR nerves around interlobular ducts and some of those in a perivascular location
remained both after sensory denervation and after extirpation of the sympathetic superior cervical ganglion. Whether these
fibres originate in dorsal root ganglia C3−C4 or represent parasympathetic fibres is not known. Based on the present data and the previous findings showing a regulatory
role of CGRP both on blood and salivary flow, it is possible that CGRP in sensory, and possibly also in parasympathetic nerves,
participates in the regulation of reflex blood flow and salivary secretion in the anterior buccal gland of the rat. |
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