Some physiological functions of the L-leucine dehydrogenase in Bacillus subtilis |
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Authors: | Norbert Obermeier Karl Poralla |
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Institution: | (1) Lehrbereich Mikrobiologie I, Institut für Biologie II der Universität, Auf der Morgenstelle 28, D-7400 Tübingen 1, Germany |
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Abstract: | Mutants of Bacillus subtilis constitutive for L-leucine dehydrogenase synthesis were selected. Using these mutants we could determine two functional roles for the L-leucine dehydrogenase. This enzyme liberates ammonium ions from branched chain amino acids when supplied as the sole nitrogen source. Another function is to synthesize from L-isoleucine, L-leucine, and L-valine the branched chain -keto acids which are precursors of branched chain fatty acid biosynthesis. These results together with the inducibility of the enzyme suggest that the L-leucine dehydrogenase has primarily a catabolic rather than an anabolic function in the metabolism of Bacillus subtilis. |
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Keywords: | Bacillus subtilis L-Leucine dehydrogenase" target="_blank">L-Leucine dehydrogenase Constitutive mutants Branched chain fatty acids |
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