Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity |
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| Institution: | 1. Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India;2. Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad Government Medical College Kangra, Tanda 176 001, Himachal Pradesh, India;3. Dr. Bansal Skin Laser Center Clinic, Board Chowk, Nac Manimajra, Chandigarh 160 002, India;1. Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Takaramachi13-1, Kanazawa, Ishikawa, Japan;2. Department of Orthopedic Surgery, Fukui General Hospital, 58-16-1 Egami, Fukui, Fukui 910-8561, Japan |
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| Abstract: | Several cytokines were assumed to play an essential role in the induction and the pathogenesis of psoriasis. The aim of this work was to investigate the role of TNF-α-308 and IL-10-1082 polymorphisms and their serum levels in the pathogenesis of psoriasis and determine their relation to disease severity. 110 Psoriasis patients and 120 healthy volunteers were genotyped for TNF-α-308 and IL-10-1082 polymorphism by polymerase chain reaction. Serum level of TNF-α and IL-10 were measured by ELISA. Our study demonstrated an association of IL-10-1082 polymorphism and psoriasis and between TNF α-308 polymorphism and psoriasis disease and severity. Serum TNF α increased in patients, while serum IL-10 decreased in patients with significant correlation between serum TNF-α and psoriasis severity. These results indicated that TNF-α-308 and IL-10-1082 polymorphisms imparted significant risk towards the development of psoriasis. |
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| Keywords: | Psoriasis IL-10 TNF-α Polymorphisms |
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