Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use |
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Authors: | Ruizhi Hou Yan Liu Ye Feng Libo Sun Zhenbo Shu Jisheng Zhao Shujuan Yang |
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Institution: | 1. Gastrointestinal Department, China–Japan Union Hospital Jilin University, Changchun 130033, China;2. Ultrasonography Department, China–Japan Union Hospital Jilin University, Changchun 130033, China;3. Department of Health and Social Behavior, West China School of Public Health, Sichuan University, Chengdu, China |
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Abstract: | We investigated the association between polymorphisms in excision repair cross-complementation group 1 (ERCC1) (rs3212986, rs2298881 and rs11615) and xeroderma pigmentosum-complementation group F (XPF) (rs2276466 and rs6498486) and risk of colorectal cancer. A 1:1 matched case–control study was conducted. Conditional regression analysis indicated that individuals carrying the ERCC1 rs3212986 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with subjects with the GG genotype. Similarly, subjects carrying the rs11615 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with those with the CC genotype. Stratified analysis revealed that individuals with rs3212986 TT who were current or former smokers had a significantly increased risk of colorectal cancer, and a significant interaction was found between this SNP and cigarette smoking. In conclusion, our study suggests that rs3212986 and rs11615 polymorphisms are associated with risk of colorectal cancer in a Chinese population, particularly in smokers. This finding could be useful in revealing the genetic characteristics of colorectal cancer, and suggests more effective strategies for prevention and treatment. |
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Keywords: | miRNAs microRNAs ERCC1 excision repair cross-complementation group 1 XPF xeroderma pigmentosum-complementation group F ERCC2 excision repair cross-complementation group 2 ERCC3 excision repair cross-complementation group 3 NER nuclear excision repair PCR polymerase chain reaction CI confidence interval 95% OR odds ratio HWE Hardy&ndash Weinberg equilibrium SNP single nucleotide polymorphism SPSS Statistical Package for Social Science DNA deoxyribonucleic acid |
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