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The BGN and ACAN genes and carpal tunnel syndrome |
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| Authors: | Marilize C Burger Hanli De Wet Malcolm Collins |
| Institution: | 1. UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa;2. Life Occupational Health, Western Cape, South Africa |
| Abstract: | The causes of idiopathic carpal tunnel syndrome (CTS) remain unknown and the involvement of the tendons within the carpal tunnel structure in the aetiology of CTS cannot be excluded. Variants within the COL5A1 gene, an important regulator of fibril assembly in tendons, have previously been associated with modulating the risk of CTS. Furthermore, proteoglycans are also important structural components of tendons and variants within the aggrecan gene are associated with musculoskeletal soft tissue injuries. The aim of this study was to determine whether ACAN and BGN variants are associated with CTS. |
| Keywords: | ANOVA analysis of variance AT Achilles tendinopathy BMI body mass index bp base pairs COL5A1 the gene encoding for the α1 chain of type V collagen CON control group CTS carpal tunnel syndrome ECM extracellular matrix HWE Hardy&ndash Weinberg Equilibrium OR odds ratio PCR polymerase chain reaction SNPs Single Nucleotide Polymorphism(s) |
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