The activation of the atypical PKC zeta in light‐induced retinal degeneration and its involvement in L‐DNase II control |
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| Authors: | Imene Jaadane Sabine Chahory Chloé Leprêtre Boubaker Omri Laurent Jonet Francine Behar‐Cohen Patricia Crisanti Alicia Torriglia |
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| Institution: | 1. INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France;2. ENVA, Ecole Nationale Vétérinaire d'Alfort, Maison Alfort, Paris, France;3. H?pital Ophtalmique Jules‐Gonin, Lausanne, Switzerland |
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| Abstract: | Light‐induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase‐independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI‐derived DNase II (LEI/L‐DNase II), a caspase‐independent apoptotic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro‐survival kinase, the protein kinase C (PKC) zeta. We show that light exposure induced PKC zeta activation. PKC zeta interacts with LEI/L‐DNase II and controls its DNase activity by impairing its nuclear translocation. These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase‐independent pathways. |
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| Keywords: | PKC zeta serpin B1 retinal apoptosis retinal degeneration light |
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