Reduced mechanical activity of perfused rat heart following morphine or enkephalin peptides administration |
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| Authors: | Carlo Clô Claudio Muscari Benedetta Tantini Carla Pignatti Pasquale Bernardi Carlo Ventura |
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| Institution: | 1. Institute of Biological Chemistry, University of Bologna, Bologna, Italy;1. II Medical Clinic, School of Medicine and Surgery, University of Bologna, Bologna, Italy |
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| Abstract: | In the isolated and perfused rat heart, the addition of morphine, methionine-enkephalin or leucine-enkephalin to the coronary perfusate, significantly reduces the mechanical activity by negatively affecting both the heart rate and the developed tension. These effects are dose dependent and maximally evident with leucine-enkephalin. Furthermore all the opioids strongly reduce the activity of isoproterenol-stimulated hearts. The suggestion is made that opioid peptides directly influence the cardiac mechanical activity possibly by interacting with membrane-receptor systems. |
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