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The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines. |
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| Authors: | J I Levin J M Chen M T Du F C Nelson T Wehr J F DiJoseph L M Killar S Skala A Sung M A Sharr C E Roth G Jin R Cowling L Di M Sherman Z B Xu C J March K M Mohler R A Black J S Skotnicki |
| Institution: | Wyeth-Ayerst Research, 401N. Middletown Rd., Pearl River, NY 10965, USA. levinji@war.wyeth.com |
| Abstract: | Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13. |
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