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Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates
Authors:Clayton M. Carey  Apurva A. Govande  Juliane M. Cooper  Melissa K. Hartley  Philip J. Kranzusch  Nels C. Elde
Affiliation:1. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA;2. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA;3. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Abstract:
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  • Keywords:oligoadenylate synthetase 1  OAS1  RNase L  rapid evolution  polymorphism  primates  loss-of-function mutation  yeast  double-stranded RNA  dsRNA
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