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Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis
Authors:Tadeusz Majewski  Hui Yao  Jolanta Bondaruk  Woonbok Chung  Sangkyou Lee  June Goo Lee  Shizhen Zhang  David Cogdell  Guoliang Yang  Woonyoung Choi  Colin Dinney  H. Barton Grossman  Christopher Logothetis  Steven E. Scherer  Charles C. Guo  Li Zhang  Peng Wei  John N. Weinstein  Bogdan Czerniak
Affiliation:1. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA;4. Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;5. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA;7. Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA;8. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;9. Johns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD, USA
Abstract:
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  • Keywords:Whole-organ map  bladder cancer  DNA methylation  DNA copy alterations  founder mutation  field effect  clonal origins  clonal expansion  urothelial carcinoma  gene signature
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